The Benova Mouth Rinse System has demonstrated a significant 17% reduction in the inflammatory marker TNF-alpha within just two minutes of application, according to a study presented by Daniel J. Gibson, PhD, at the 2025 Diabetic Limb Salvage Conference. This finding is particularly relevant for millions suffering from oral mucositis, a condition affecting 51% of chemotherapy patients, and recurrent aphthous stomatitis (RAS), prevalent in 25% of the general population, where TNF-alpha plays a critical role in inflammation and tissue damage.

Conducted at the University of Alabama Capstone College of Nursing, the research utilized an in vitro model to simulate inflamed oral mucosa, akin to that seen in cancer therapy patients or those with chronic inflammatory wounds. The study highlights the Benova Mouth Rinse System’s ability to swiftly mitigate inflammation without relying on lidocaine, steroids, or prescription drugs, marking a potential breakthrough in pain relief and healing support through targeted cytokine reduction.

Bill Kling, Benova’s co-founder, emphasized the alignment between the study’s outcomes and user testimonials regarding rapid pain and inflammation relief from oral ulcers. The presentation of these findings at the Diabetic Limb Salvage Conference underscores the product’s relevance in wound care and tissue regeneration, fields that are central to the conference’s interdisciplinary focus on diabetic foot and limb wounds.

The Benova Mouth Rinse System, designed for conditions like stomatitis and oral mucositis, is already in use by a wide range of healthcare professionals, including oncologists and dentists, to provide immediate relief from mouth sores. This study not only validates the product’s mechanism of action but also its potential to enhance quality of life for patients dealing with painful oral conditions.

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